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INDIANAPOLIS — On the first play of the Ravens season, wide receiver Zay Flowers caught a 49-yard pass. After five catches and 150 receiving yards, he was sidelined by a hamstring injury Sunday in the opener against the Indianapolis Colts.

After his monster start got the Ravens’ offense rolling, Flowers’ absence slowed their momentum. He had five of the team’s 12 catches and was the only wide receiver other than rookie Ja’Kobi Lane to make a catch prior to his injury.

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Flowers spent the final minutes of the first half standing next to general manager Eric DeCosta and was gesturing toward his hamstrings. He had a hamstring injury in training camp, as well.

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To start the second half, Flowers was standing on the sideline in a baseball hat but initially he was not ruled out of the game. He was downgraded later in the half.

And Lane joined him on the injury list.

Lane, who had one catch for 11 yards, along with a touchdown that was called back by a holding penalty, hurt his wrist on the first drive of the second half.

The Ravens placed two wide receivers, Elijah Sarratt and Devontez Walker, on the inactive list as healthy scratches. The remaining active wide receivers are Rashod Bateman, Chris Moore and LaJohntay Wester.

The Ravens also lost cornerback TJ Tampa early in the game. Tampa, a third-year player, was limited through his rookie season by injuries and has spent the last two years working his way into a larger role. He walked off the field with a trainer less than three minutes into the game and was ruled out quickly after because of a knee injury.

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This article has been updated.